Warnings 警告

Rarely, serious (sometimes fatal) asthma-related breathing problems have occurred with the use of long-acting inhaled beta agonists (eg, salmeterol).很少，严重（有时是致命的）哮喘有关的呼吸问题发生与使用长效吸入乙型受体激动剂（如沙美特罗） 。 This product contains salmeterol in combination with fluticasone (a corticosteroid).本产品含有沙美特罗联合替卡松（一类固醇） 。 It is not known if adding a corticosteroid changes this risk.目前尚不清楚，如果增加了类固醇这一风险的变化。 Therefore, in patients with asthma, this drug should only be prescribed when one long-term medication (eg, inhaled corticosteroids) does not control breathing problems or when more than one long-term medication is clearly needed to control breathing problems.因此，哮喘患者，这种药物只应订明当一个长期服药（例如，吸入糖皮质激素）不控制呼吸问题或一个以上的长期服药显然是需要控制呼吸困难。 Before using this medication, it is important to learn how to use it properly.在使用这种药物，重要的是要学习如何正确地使用它。 Discuss the risks and benefits of treatment with this medication with your doctor.讨论的风险和好处的治疗药物与此同你的医生。

Uses 利用

This product is a combination medication (salmeterol and fluticasone).该产品是结合药物（沙美特罗替卡松） 。 It is used as a long-term (maintenance) treatment to prevent or decrease wheezing and trouble breathing caused by asthma or ongoing lung disease (eg, COPD, emphysema).这是作为一个长期（维护）治疗，以防止或减少哮喘和呼吸困难引起的哮喘或正在进行的肺部疾病（如慢性阻塞性肺病，肺气肿） 。 It works in the airways by decreasing swelling and relaxing muscles.它在通过降低呼吸道肿胀和放松肌肉。 Controlling symptoms of breathing problems can decrease time lost from work or school.控制症状，呼吸困难可以减少损失的时间从上班或上学。

This medication does not work immediately and should not be used for sudden attacks of breathing trouble.这种药物不会立即开展工作，不应该被用于袭击的突然呼吸困难。 Your doctor must prescribe a quick-relief medicine/inhaler (eg, albuterol) for sudden shortness of breath/asthma attacks while you are on this medication.你的医生处方必须快速救援医学/吸入器（如沙丁胺醇）突发呼吸急促/哮喘发作，而你对这个药物。 You should always have a quick-relief inhaler with you.您应该始终有一个快速救济吸入与您联系。 Consult your doctor or pharmacist for more details.咨询您的医生或药剂师的更多细节。

Do not use other long-acting inhaled beta agonists (eg, salmeterol, formoterol) with this product since this may increase your risk for side effects.不要使用其他长效吸入乙型受体激动剂（如沙美特罗，福莫特罗）与此产品，因为这可能会增加您的风险的副作用。

In patients with asthma, this medication should not be used when breathing problems can be controlled with inhaled corticosteroids (eg, flunisolide, fluticasone) and occasional use of quick-relief inhalers.在哮喘患者，这种药物不应当被用来呼吸困难时，可以控制吸入皮质类固醇（例如， flunisolide ，替）和偶尔使用的快速救援吸入。 (See also Warning section.) （亦见警告一节。 ）

If you are regularly taking corticosteroids by mouth (eg, prednisone), you should not stop using them or use this inhaled medication instead.如果您经常考虑皮质类固醇的口（如强的松） ，你不应该停止使用或使用该吸入药物代替。 Continue to follow your doctor's instructions on taking the corticosteroids by mouth.继续按照你的医生的指示，采取了类固醇的嘴。

Read the Medication Guide available from your pharmacist before you start using salmeterol/fluticasone and each time you get a refill.阅读用药指南可以从您的药剂师，然后再开始使用沙美特罗/氟替卡松和每次获得充值。 Refer to the illustrated directions provided by the manufacturer for directions on how to use this device.参考方向说明制造商所提供的指示如何使用这个装置。 If any of the information is unclear, consult your doctor or pharmacist.如果有任何的资料不清楚，咨询您的医生或药剂师。

Always activate and use this device in a level, horizontal position.始终激活，并利用这种装置在一个新的台阶，水平位置。

Inhale this medication by mouth, usually twice daily in the morning and the evening (12 hours apart), or use as directed by your doctor.吸入这种药物的嘴，通常每天两次在上午和晚上（相差12小时） ，或使用的指示你的医生。 You may or may not taste/feel the drug when you inhale.您可能会或不会味道/感觉的药物时，吸气。 Either is normal.无论是正常的。 Never exhale into the device.从来没有呼出的设备。 Do not use with a spacer.不要使用有间隔。 Never wash the mouthpiece or any part of the device.从来没有洗的喉舌或任何部分的设备。 Do not take the inhaler apart.不要吸入四分五裂。

Gargle and rinse your mouth with water after using this medication to help prevent dryness and mouth infections (eg, thrush) and relieve throat irritation.漱口液和冲洗你的嘴与水后，使用此药，以帮助防止干燥和口蹄疫感染（如鹅口疮）和减轻喉咙发炎。 Do not swallow the rinse water.不要吞下冲洗水。

The dosage is based on your medical condition and response to therapy.剂量是根据您的医疗条件和治疗反应。 Use this medication regularly to receive the most benefit from it.使用此药定期收到最从中受益。 To help you remember, use it at the same times each day.为了帮助您记住，使用它在同一时间每一天。 Do not use it more than prescribed or use more than 1 inhalation twice daily since this may increase the risk of side effects.不要使用它超过订明或使用超过1吸入，每天两次，因为这可能会增加危险的副作用。

Do not stop taking this medication or change your dose without consulting your doctor.不要停止服用这种药物或更改您的剂量没有咨询您的医生。 Some conditions may become worse when the drug is suddenly stopped.一定条件下可能会变得更糟时，药物的突然停止。 Your dose may need to be gradually decreased.您的剂量可能需要逐渐下降。

If you have been using a quick-relief inhaler (eg, albuterol) on a regular daily schedule (such as 4 times daily), you must stop this schedule and only use it as needed for sudden shortness of breath/asthma attacks.如果你一直在使用一种快速救济吸入（如沙丁胺醇）经常每日时间安排（如每天4次） ，您必须停止这个时间表，只有利用它作为需要突然呼吸急促/哮喘发作。 Consult your doctor for details.你的医生咨询详情。

If this medication stops working well, or you need to use your quick-relief inhaler more often than usual (4 or more puffs daily or use of more than 1 inhaler every 8 weeks), seek immediate medical attention.如果这种药物停止工作，或您需要使用您快速救济更经常吸入比平常（ 4或更多的喷每日或使用超过1吸入每8个星期） ，立即寻求医疗照顾。 It may be a sign of worsening asthma, which is a serious condition.这可能是一种迹象日益恶化的哮喘，这是一个严重的状况。

It may take 1 week or longer before the full benefit of this drug takes effect.这可能需要1周或更长的时间之前，充分利用这种药物影响。 Inform your doctor if your condition persists or worsens.通知你的医生如果您的条件依然存在或恶化。

Side Effects 副作用

Hoarseness, throat irritation, headache, rapid heartbeat, nervousness, cough, dry mouth/throat, or upset stomach may occur.声音沙哑，喉咙发炎，头痛，心跳加快，紧张，咳嗽，口干/喉咙，或肠胃不适，可能会发生。

To relieve dry mouth, suck on (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute.为减轻口干，吸（无糖）硬糖果或冰芯片，咀嚼（无糖）口香糖，喝水，或使用唾液替代品。

If any of these effects persist or worsen, notify your doctor or pharmacist promptly.如果这些影响持续或恶化，通知您的医生或药剂师迅速。

Remember that your doctor has prescribed this medication because the benefit to you is greater than the risk of side effects.请记住，您的医生处方用药，因为这有利于你是大于风险的副作用。 Many people using this medication do not have serious side effects.许多人使用这种药物并没有严重的副作用。

Tell your doctor immediately if any of these unlikely but serious side effects occur: white patches on tongue/in mouth, increased thirst/urination, persistent weight gain, vision problems (eg, blurred vision), shaking.告诉您的医生立即如果任何这些不太可能，但严重的副作用发生：白色补丁的舌头/口，增加口渴/排尿，持续的体重增加，视力问题（例如，视力模糊） ，颤抖。

Tell your doctor immediately if any of these rare but very serious side effects occur: chest pain, fast/slow/irregular heartbeat, seizures, severe muscle cramping.告诉您的医生立即如果任何这些罕见但非常严重的副作用发生：胸痛，快/慢/心律不齐，痉挛，严重的肌肉痉挛。

An allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs.过敏反应，这种药物是不可能的，但也立即寻求医疗照顾，如果它发生。 Symptoms of an allergic reaction include: rash, itching, swelling, severe dizziness, trouble breathing.症状的过敏反应包括：皮疹，发痒，肿胀，严重的头晕，呼吸困难。

Rarely, this medication has caused severe (rarely fatal), sudden worsening of breathing problems/asthma (paradoxical bronchospasm).很少，这种药物已造成了严重的（很少致命的） ，突然恶化，呼吸困难/哮喘（自相矛盾的支气管痉挛） 。 If you have trouble breathing or experience sudden wheezing, use your quick-relief inhaler and seek immediate medical attention.如果您有呼吸困难或突然喘息的经验，使用快速救济吸入，并寻求紧急医疗的重视。

This is not a complete list of possible side effects.这不是一个完整名单可能带来的副作用。 If you notice other effects not listed above, contact your doctor or pharmacist.如果您发现其他效果没有在上面列出，请联系您的医生或药剂师。

Precautions 防范措施

Before using this medication, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.在使用这种药物，请告诉您的医生或药剂师如果你是过敏的情况;或者，如果您有任何其他过敏。

Before using this medication, tell your doctor or pharmacist your medical history, especially of: high blood pressure, brittle bones (osteoporosis), depression, diabetes, eye problems (eg, cataracts, glaucoma), heart problems (eg, angina, irregular heartbeat), any recent infection, liver problems, low potassium levels (hypokalemia), seizures, smoking, thyroid problems (eg, overactive thyroid).在使用这种药物，请告诉您的医生或药剂师您的医学史，特别是：高血压，骨骼脆弱（骨质疏松症） ，抑郁症，糖尿病，眼睛问题（如白内障，青光眼） ，心脏问题（如心绞痛，心律不齐） ，任何最近的感染，肝脏疾病，钾水平低（低血钾） ，癫痫发作，吸烟，甲状腺的问题（例如，甲状腺过度） 。

This product may make you dizzy; use caution engaging in activities requiring alertness such as driving or using machinery.此产品可让你头晕目眩;使用谨慎从事，需要警觉，如驾驶或使用机器。 Limit alcoholic beverages.限制含酒精饮料。

Avoid contact with people who have chickenpox or measles unless you have previously had these diseases (eg, in childhood).避免接触的人谁也水痘或麻疹除非你有以前这些疾病（例如，在儿童） 。 If you are exposed to one of these infections and you have not previously had it, seek immediate medical attention.如果你接触到这些感染和你之前没有它，立即寻求医疗照顾。

If you have switched from an oral corticosteroid (eg, prednisone tablets) to this inhaler within the past 12 months, or if you have been using this product for an extended time and suddenly stop using it, your body may not produce enough natural steroids.如果您有转自口头皮质类固醇激素（如强的松片）本吸入在过去12个月，或者如果您已使用本产品延长时间，突然停止使用它，你的身体可能不会产生足够的天然类固醇。 You may need to start taking additional corticosteroids, especially if your body is stressed due to a major infection, surgery, or injury.您可能需要开始采取更多的激素，尤其是如果你的身体是强调，由于一个主要感染，手术，或伤害。 Deaths have sometimes occurred during such stresses due to low steroid levels.死亡的过程中有时会发生这样讲由于激素水平低。 Tell your doctor immediately if any of the following side effects occur: unusual weakness, sudden weight loss, dizziness.告诉您的医生立即如果下列任何副作用发生：不寻常的弱点，突然体重减轻，头晕。 Consult your doctor or pharmacist for more details, and inform them that you use (or have used) any type of corticosteroid.咨询您的医生或药剂师的更多细节，并通知他们您使用（或使用）任何类型的类固醇。 Consult your doctor or pharmacist now for advice regarding future stress situations.咨询您的医生或药剂师的意见现在就今后的应力情况。 You may need to carry a supply of corticosteroid tablets as a precaution.您可能需要携带一个供应皮质类固醇片，以防万一。 Carry a warning card or medical ID bracelet that identifies your need for oral corticosteroids during times of stress as noted.贯彻警告卡或医疗编号手镯，用来标识您的需要口头皮质类固醇期间强调指出。 (See also Medical Alert section.) （又见医疗快讯节。 ）

Caution is advised when using this drug in the elderly because they may be more sensitive to the effects of the drug, especially dizziness and the effects on the heart.建议谨慎使用这种药物在老年人，因为他们可能更敏感的影响，药物，尤其是头晕和影响心脏。

Caution is advised when using this drug in children.建议谨慎使用这种药物的儿童。 Though it is unlikely to occur with inhaled steroids, this medication may temporarily slow down a child's rate of growth, but it will probably not affect final adult height.虽然这是不可能发生吸入类固醇，此药物可能会暂时放缓孩子的增长速度，但它可能不会影响到最后的成年身高。 Monitor your child's height periodically.监控您的孩子的身高定期。

During pregnancy, this medication should be used only when clearly needed.在怀孕期间，这个药物应该只用时显然需要。 Discuss the risks and benefits with your doctor.讨论风险和收益与您的医生。

It is not known if salmeterol or fluticasone pass into breast milk.现在还不知道，如果替沙美特罗或进入母乳。 Based on information for similar drugs, fluticasone may pass into breast milk.基于信息的类似药品，替可进入母乳。 Consult your doctor before breast-feeding.你的医生咨询之前，母乳喂养。

Interactions 互动

Your healthcare professionals (eg, doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for them.您的医护专业人员（如医生或药剂师）可能已经意识到任何可能的药物相互作用，可能是监测你为他们。 Do not start, stop or change the dosage of any medicine before checking with them first.不要启动，停止或改变剂量任何药物检查前与他们第一次。

This drug should not be used with the following medication because very serious interactions may occur: natalizumab.这种药物不应当被用来与下列药物，因为非常严重的相互作用，可能会发生：那他珠单抗。

Avoid taking MAO inhibitors (eg, furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, selegiline, tranylcypromine) within 2 weeks before, during, and after treatment with this medication.避免采取毛抑制剂（如呋喃唑酮， isocarboxazid ，利奈，吗氯贝胺， phenelzine ，苄肼，吉林， tranylcypromine ） 2周内之前，期间和治疗后与此药品。 In some cases a serious, possibly fatal drug interaction may occur.在某些情况下，严重的可能致命的药物相互作用，可能会发生。

If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting this product.如果您目前使用任何这些药物在上面列出，告诉你的医生或药剂师在开始这项产品。

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially: aldesleukin, other asthma drugs (eg, quick-relief inhalers), beta blockers (eg, metoprolol, propranolol), corticosteroids taken by mouth (eg, dexamethasone, prednisone), HIV protease inhibitors (eg, ritonavir), inhaled anesthetics (eg, halothane), drugs affecting liver enzymes that remove this medication from your body (such as azole antifungals including itraconazole, macrolide antibiotics including erythromycin, cimetidine, rifamycins including rifabutin, St. John's wort, certain anti-seizure medicines including carbamazepine), mifepristone, tricyclic antidepressants (eg, amitriptyline, nortriptyline), "water pills"/diuretics (eg, furosemide, hydrochlorothiazide).在使用这种药物，请告诉您的医生或药剂师的所有处方药和非处方/草药产品可以使用，特别是： aldesleukin ，其他哮喘药物（例如，快速救援吸入） ， β -受体阻滞剂（如美托洛尔，普萘洛尔） ，采取类固醇经口（例如，地塞米松，强的松） ， HIV蛋白酶抑制剂（例如，利托那韦） ，吸入麻醉药（如氟烷） ，药物影响肝酶，消除这种药品从您的机构（如氮唑antifungals包括伊曲康唑，大环内酯类抗生素，包括红霉素，西咪替丁，利福霉素包括利福布丁，圣约翰麦汁，某些反扣押的药品包括卡马西平） ，米非司酮，三环抗抑郁药（如阿米替林，甲替林） ， “水药片” /利尿剂（如速尿，氢氯噻嗪） 。

Other drugs besides this product which may affect the heart rhythm (QTc prolongation in the EKG) include dofetilide, pimozide, procainamide, amiodarone, quinidine, sotalol, and erythromycin, among others.其他药物此产品除可能影响心脏节律（ QT间期延长的心电图） ，包括多非利特，匹莫齐特，普鲁卡因，胺碘酮，奎尼丁，索他洛尔，和红霉素等。 QTc prolongation can infrequently result in serious (rarely fatal) irregular heartbeats. QT间期延长可以经常导致严重的（很少致命）心律不齐。 Consult your doctor or pharmacist for more details and for instructions on how you may minimize the risk of this effect.咨询您的医生或药剂师的更多细节，并说明如何可以尽量减少这种效应。

Check the labels on all your medicines (eg, cough-and-cold products, diet aids) because they may contain ingredients that could increase your heart rate or blood pressure.检查标签上所有的药品（如咳嗽和感冒的产品，饮食艾滋病） ，因为它们可能含有成分，可以增加您的心率和血压。 Ask your pharmacist about the safe use of these products.问问你的药剂师有关安全使用这些产品。

This document does not contain all possible interactions.这份文件并不包含所有可能的相互作用。 Therefore, before using this product, tell your doctor or pharmacist of all the products you use.因此，在使用本产品，请告诉您的医生或药剂师的所有产品使用。 Keep a list of all your medications with you, and share the list with your doctor and pharmacist.请列出您所有的药物与你分享的名单和你的医生和药剂师。