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Advanced Reading: Bipolar Disorder Psychotherapy高级如下:双相情感障碍的心理治疗 PDF格式 打印 电子邮箱
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Friday, 04 January 2008周五, 08年一月四日
Article Index文章索引
Advanced Reading: Bipolar Disorder Psychotherapy 高级如下:双相情感障碍的心理治疗
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Introduction导言

Michael E. Thase, MD 迈克尔酶,医学博士

Bipolar affective disorder is commonly thought of as the most "biological" form of mood disorder and, perhaps for this reason, the role of psychotherapy historically has received relatively short shrift. [1] However, several factors came together in the 1990s that fueled a renewed interest in examining the role of psychotherapy in bipolar affective disorder, particularly if used in combination with pharmacotherapy. [1-3] Perhaps of greatest importance, there was a recognition that even medications with well-established preventive efficacy, such as lithium salts, often failed to protect patients from relapse and recurrence. [4,5] Other research established that psychosocial risk factors, including inadequate social support, adverse life events, and medication nonadherence, were often linked to the relapse risk. [6-8] It was proposed that psychosocial interventions that targeted these risk factors could have the potential to complement the effects of pharmacotherapy.双相情感障碍通常认为是最“生物”形式的心境障碍,或许由于这个原因,心理治疗作用的历史已收到不理会相对较短。 [ 1 ]然而,几个因素共同在20世纪90年代引发新的兴趣在审查中的作用心理双相情感障碍,尤其是如果结合使用药物治疗。 [ 1-3 ]也许最重要的,有一种认识,甚至药物与公认的预防效果,如锂盐,往往未能保护病人的复发和复发。 [ 4,5 ]其他研究确定,心理社会危险因素,包括不健全的社会支持,不良生活事件,药品nonadherence并,往往是联系在一起的复发风险。 [ 6-8 ]它有人提议,心理干预,有针对性,这些危险因素有潜力,以补充药物的影响。 Although development of even more effective and better-tolerated pharmacotherapies remained a high public health priority, the time is ripe to evaluate the utility of focused forms of psychotherapy in combination with the existing standard medications.虽然发展更有效和更不能容忍pharmacotherapies仍然是一个很高公共卫生的优先事项,现在时机已经成熟,评估的效用集中形式的心理治疗结合现有的标准药物。

It was not necessary to develop psychotherapies for bipolar disorder from scratch.这是没有必要制订心理治疗的躁郁症从零开始。 Drawing upon research conducted in patients with schizophrenia, therapies focusing on improving family support and psychoeducation were available. [9-11] Likewise, in the area of nonbipolar depression, there were well-developed, procedurally specified interventions that focused on cognitive, behavioral, and interpersonal aspects of depression. [12,13] Thus, in relatively short order, manuals for psychoeducational, [14] family-dyadic, [15] cognitive-behavioral, [16] and interpersonal [17] models of treatment for bipolar affective disorder were developed.借鉴进行研究精神分裂症患者,治疗重点是改善家庭支持和psychoeducation都已经具备。 [ 9-11 ]同样,在该地区的nonbipolar抑郁症,有相当发达,在程序上指定的干预,侧重于认知,行为,和人际关系方面的抑郁症。 [ 12,13 ]因此,在相对较短的秩序,手册,教育心理 [ 14 ]家庭配对 [ 15 ]认知行为 [ 16 ]和人际关系[ 17 ]模型的治疗双相情感制定了混乱。 A number of studies evaluating these therapies now have been completed and, in the following sections, the evidence pertaining to each of these models will be examined.一些研究评估这些疗法目前已经完成,并在下面的部分,有关的证据逐一向这些车型将予以审查。

Review of Outcome Studies of Psychotherapies for Bipolar Disorder审查结果的研究心理治疗的躁郁症

Randomized controlled trials (RCTs) have been completed evaluating 4 forms of psychotherapy for adjunctive treatment of bipolar disorder.随机对照试验(对照试验)已完成第4评价形式的心理治疗的辅助治疗躁郁症。 These empirically validated interventions include: (1) psychoeducation, (2) cognitive behavioral therapy (CBT), (3) family focused therapy (FFT), and (4) interpersonal and social rhythm therapy (IPSRT).这些经验验证的干预措施包括: ( 1 ) psychoeducation , ( 2 )认知行为疗法(金牌) , ( 3 )注重家庭治疗(傅立叶变换) ,和( 4 )人际关系和社会节奏疗法( IPSRT ) 。 Despite some conceptual and procedural overlap, these interventions differ with respect to the frequency and duration of sessions and use of specific interventions.尽管取得了一些概念和程序重叠,这些干预与尊重不同的频率和会期和使用的具体干预。 Thus, although all 4 interventions might be expected to capitalize on similar nonspecific therapeutic ingredients, they also might be expected to differentially affect selected aspects of bipolar illness.因此,尽管4个干预可能会预计将利用类似的非特异性治疗成分,但它们也可能是预期差异影响某些方面的双极疾病。

Psychoeducation

The first study of psychoeducation was conducted by Perry and colleagues. [18] These investigators evaluated the impact of 7 to 12 individual psychoeducational sessions addressing medication adherence, early recognition of prodromal symptoms and impending relapse, and rapid intervention to forestall relapse.第一项研究的psychoeducation进行了佩里和他的同事。 [ 18 ]这些调查评价的影响, 7至12个人的教育心理会处理药物的加入,早日承认前驱症状和即将到来的复发,并迅速进行干预,以防止复发。 The 69 remitted bipolar I patients taking mood stabilizers were randomized to receive either treatment as usual (TAU) or "add on" psychoeducational sessions. 69汇两极我病人服用情感稳定剂被随机分配接受治疗像往常一样(赵军)或“新增的”教育心理会议。 When compared with the TAU group, patients receiving psychoeducation had a significantly lower risk of manic relapse (18% vs 46%) and significantly better social and vocational functioning.当与赵军组,患者接受psychoeducation有显着降低复发躁狂( 18 %比46 % )和显着更好的社会和职业运作。 Patients receiving therapy also were at somewhat lower risk for depressive relapse (ie, 31% vs 48%), although this difference was not statistically significant.患者接受治疗时也有一定的风险降低抑郁症复发(即31 %比48 % ) ,但这种差异并不显着。

The second RCT evaluated a group model of psychoeducation, [19] which consisted of up to 21 sessions over 5 months.第二次随机对照试验评价一组模型psychoeducation [ 19 ]其中包括21届会超过5个月。 A total of 120 outpatients with bipolar I or II disorder receiving ongoing therapy with mood stabilizers participated in the study.共有120个门诊双相I或II障碍正在接受治疗情绪稳定剂参与了此项研究。 Participants were randomized to receive adjunctive treatment with either group psychoeducation or an attention-placebo control group focusing on social support and nondirective discussion.参加者随机接受辅助治疗的两组psychoeducation或注意安慰剂对照组侧重于社会的支持和非指导讨论。 Across 2 years of follow-up, patients randomized to group psychoeducation experienced a significantly lower number of recurrences (67% vs 92%) as well as a significantly longer duration of sustained remission.跨越2年的后续行动,病人随机组psychoeducation经历了一个显着降低复发人数( 67 %比92 % )以及一个显着较长的持续缓解。



 
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