Medication is used for an anterior cruciate ligament (ACL) injury to relieve or reduce pain. It also may be used for long-term (chronic) ACL deficiency and during the rehabilitation period. Nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin and ibuprofen, are commonly used. NSAIDs are available with or without a prescription.

NSAIDs may cause stomach upset and should be taken with food and a glass of water. They can have side effects and should not be taken with certain other medications. Let your health professional know what other medications you are taking. Do not give aspirin to anyone younger than 20 because of the risk of Reye's syndrome.

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